Abstract: Antimicrobial peptides, as a promising substitute for traditional antibiotics, have diverse resources, high antimicrobial effects and low probability to cause bacterial resistance.However, antimicrobial peptides are easy to be degraded and not stable in antimicrobial properties, which must be improved by incorporating with macromolecules.Not only increase the stability and lower the cytotoxicity, combining with polysaccharides could also endow antimicrobial peptides with more functions.Polysaccharides gel could be mixed with antimicrobial peptides, forming into hydrogels, microparticles, membranes, etc.; copolymerization of some anionic polysaccharides and cationic antimicrobial peptides could form into copolymerized hydrogels or microparticles.Moreover, some polysaccharides could also be grafted with antimicrobial peptides through amidation, maillard or “Click” reactions aided with reaction auxiliaries.In this review, related studies in recent years were summarized and future research directions were discussed.