Abstract: The extraction process of ferulic acid from green wheat bran by ultrasonic-assisted alkali-alcohol method was studied by means of HPLC-DAD detection method. The HPLC standard curve of ferulic acid was established, and the regression equation was Y=25 159X+97.026 (R²=0.999 4, n=5). Through single factor experiments, the effects of alkali-alcohol volume ratio, alkali mass fraction, ultrasonic power, and ultrasonic temperature on ferulic acid extraction rate were investigated, and the extraction process was optimized through response surface method. The results showed that the regression equation between the ferulic acid extraction rate and the influencing factors was built; the optimal extraction conditions were determined as follows: material-to-liquid ratio of 1∶12 (g/mL), alkali mass fraction of 4.56%, alkali-alcohol volume ratio of 2.3∶1, ultrasonic time of 30 min, ultrasonic temperature of 57 ℃, and ultrasonic power of 240 W. Under the optimal conditions, the extraction rate of ferulic acid from green wheat bran reached 85.68%, which was approximately consistent with the predicted value.