Abstract: The unique properties of lipases such as better specificity, high catalytic efficiency and environmental friendliness enable them as the industrially important biocatalysts. The lipase immobilization technology expands the practical application of lipases since it overcomes the limitations of free lipase, such as easy inactivation, poor stability and difficulty in recovery. In recent years, as an emerging type of carriers for lipase immobilization, metal-organic frameworks (MOFs) materials have attracted great attentions in academic fields due to their unique properties, such as high surface area and pore volume, the ease of pore size tuning, the facile modification on both metal nodes and ligands as well as mild synthetic conditions. This review summarized the recent advances in immobilized lipase on MOFs with emphasis on the immobilization methods and modes of lipase on MOFs, including surface attachment, covalent linkage, pore encapsulation, and co-precipitation. The advantages and limitations of different methods were analyzed as well. An outstanding improvement in catalytic efficiency, enhanced stability (thermal stability, pH stability, organic solvent stability, and storage stability), promising recyclability and high selectivity are some of the fascinating features of the novel MOF-lipase composites. In addition, the potential application of lipase-MOF composites in the fields of hydrolysis, esterification, transesterification and other biocatalysis was discussed. Finally, the application of MOFs in lipase immobilization and the application of lipase-MOF composites in the field of biocatalysis are prospected.