粮食中赭曲霉毒素A生物清除方法研究进展

    Research progress on biological removal methods of ochratoxin A in grain

    • 摘要: 赭曲霉毒素A (OTA)是粮食饲料中常见的一类真菌毒素,具备较强的致癌性、致畸性和致突变性,所造成的粮食污染涉及产、购、储销、运等全产业链环节,从而带来较为严重的食品安全隐患。综述了近年来粮食中OTA防控与清除的不同方法,深入探讨了生物清除方法,在分子结构层面从酰胺键、内酯环的水解以及异香豆素环的脱氯羟基化角度进一步分析了OTA生物降解的作用机制,总结了粮食饲料中OTA生物脱毒所面临的挑战,并对其未来发展方向进行了展望,旨在为粮食饲料中OTA的生物脱毒应用提供参考。

       

      Abstract: Ochratoxin A (OTA) is a common class of mycotoxin found in food crops, possessing potent carcinogenic, teratogenic, and mutagenic properties. Contamination caused by OTA affects the entire industry chain, such as production, purchase, storage, processing, marketing, and transportation, posing severe food safety risks. In this paper, we reviewed the different methods for prevention, control, and removal of OTA in grains over recent years, with in depth discussion on biological removal methods. From the perspective of molecular structure, the mechanism of OTA biodegradation are further analyzed in terms of hydrolysis of amide bonds and lactone rings, and the dechlorination and hydroxylation of the isocoumarin ring. Additionally, the challenges faced in biological detoxification of OTA in food and feed are summarized, and future directions are outlined. The aim is to provide a reference for the application of OTA biological detoxification in grain and feed.

       

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