Abstract: Perfluorinated/polyfluorinated compounds (PFAS) are a class of emerging persistent organic pollutants that pose a serious threat to the ecological environment and food safety. Therefore, accurate qualitative and quantitative detection of PFAS in complex food matrices is particularly important. As an emerging sample pretreatment technology, solid phase extraction (SPE) has been widely applied in the field of analytical detection and achieved good results. This review summarizes the current status of four SPE technologies (column solid-phase extraction, dispersive solid-phase extraction, solid-phase microextraction, and magnetic solid-phase extraction) for the detection of PFAS in food, elaborates on the characteristics and principles of each technology, and prospects their future application and development.