Abstract: Exploring the effects of Rhyzopertha dominica of different development stages infestation on wheat lipids provides some references for the safe storage of wheat.The effects different developmental stages of R.dominica infestation on the changes of crude lipids content,fatty acid value and the fatty acid compositions in wheat were investigated.The results showed that the crude lipids contents decreased obviously with the R.dominica growth and development in the wheat kernels.The egg and larval stages resulted in the largest decline from 4.09% to 2.04%,with a decrease range of 50.1%.During the larval stage to pupa stage and pupa stage to the adult stage,the decline rate was slow,and the each stage had significant difference compared with the original stage,while there was no significant difference between the pupal stage and the adult stage.Fatty acid value sustained increasing,the change of larvae stage to pupae stage was not obvious.The change of pupae stage to adult stage was the most obvious and the range of change was the largest.There was significant difference between each stage and the original sample.The composition of fatty acids in whole wheat flour changed,and the fatty acid components varied greatly in different periods,with significant differences in various range.The results showed that the crude lipid content,fatty acid value and fatty acid composition of wheat were affected by R.dominica of different growth stages.Therefore,during the storage period,the number of R.dominica and their development stages should be paid more attention.