ADVANCE IN STUDY ON CYCLIC LIPOPEPTIDES PRODUCED BY BACILLUS

Bacillus is a kind of Gram-positive bacteria that can withstand heat,acid and alkali,and produce many kinds of antimicrobial substances.The cyclic lipopeptide from Bacillus has attracted much attention due to its structural diversity and many biological functions.Cyclic lipopeptide is composed of a peptide ring and fatty acid chain.It has hydrophilic and lipophilic property.Cyclic lipopeptide has diverse function such as antibacterial,antifungal,anti-inflammatory,antitumor and antiviral and therefore it has potential application value in biological control,environmental protection and medical treatment.The research progresses of cyclic lipopeptides in structuralfeatures ofdifferenttypes,many biologicalfunctions,biosynthesis mechanisms,separation and purification processes,structural identification methods and screening techniques for new cyclic were reviewed in this paper.Finally,the shortcomings,solutions and future development of cyclic lipopeptides were discussed and prospected.The aim is to help more researchers to quickly understand the information of cyclic lipopeptide.At the same time,it also provides a theoretical reference for the development and utilization of the new cyclic lipopeptide.